Quercetin
Quercetin. Quercetin is a type of plant pigment called a flavonoid. Many fruits and vegetables contain quercetin. Studies over the last few decades have found that quercetin intake is linked to reduced cardiovascular disease. More recently, intervention studies in animals and humans have shown that quercetin supplementation lowers blood pressure.66 Quercetin is thought to lower blood pressure through multiple mechanisms, including functioning as an angiotensin receptor blocker (ARB). In fact, a 2015 study showed quercetin achieved a similar estimated receptor docking score for the angiotensin receptor as some pharmaceutical ARBs, including irbesartan and losartan.67
The blood-pressure-lowering capacity of quercetin has been observed in several clinical trials. For example, a trial in 93 overweight or obese individuals showed 150 mg of supplemental quercetin daily for six weeks reduced systolic blood pressure by 2.6 mm Hg.
Quercetin is a principal flavonoid compound and an excellent free-radical-scavenging antioxidant that promotes apoptosis. In vitro it shows some antitumor activity in oral cancer and leukemia.[9][10][11] Cultured skin and prostate cancer cells showed significant mortality (compared to nonmalignant cells) when treated with a combination of quercetin and ultrasound.[12] Note that ultrasound also promotes topical absorption by up to 1,000 times, making the use of topical quercetin and ultrasound wands an interesting proposition.[13]
High dietary intake of fruits and vegetables is associated with reduction in cancer, and some scientists, such as Gian Luigi Russo at the Institute of Food Sciences in Italy, suspect quercetin may be partly responsible.[14][15] Research shows that quercetin influences cellular mechanisms in vitro and in animal studies.[16] According to the American Cancer society, “there is no reliable clinical evidence that quercetin can prevent or treat cancer in humans”.[17]
https://en.wikipedia.org/wiki/Experimental_cancer_treatment
http://www.ncbi.nlm.nih.gov/pubmed/26609631
Quercetin inhibits multiple pathways involved in interleukin 6 secretion from human lung fibroblasts and activity in bronchial epithelial cell transformation induced by benzo[a]pyrene diol epoxide.
quercetin, a dietary compound having preventive properties for lung cancer, decreased BPDE-stimulated IL-6 secretion from human lung fibroblasts through inhibition of the NF-κB and ERK pathways
Grape Seed Extract
https://www.healthline.com/nutrition/grape-seed-extract-benefits#6.-Can-improve-kidney-function
10 Benefits of Grape Seed Extract, Based on Science
- . Can reduce blood pressure -A review of 16 studies in 810 people with high blood pressure or an elevated risk of it found that taking 100–2,000 mg of GSE daily significantly reduced systolic and diastolic blood pressure (the top and bottom number) by an average of 6.08 mmHg and 2.8 mmHg, respectively.
- Can improve blood flow- in an 8-week study in 17 healthy postmenopausal women, taking 400 mg of GSE had blood-thinning effects, potentially reducing the risk of blood clot
- Could reduce oxidative damage-GSE may help reduce your risk of heart disease by inhibiting the oxidation of LDL (bad) cholesterol and reducing oxidation to heart tissue during times of stress.
- May improve collagen levels and bone strength-Animal studies show promising results regarding GSE’s ability to help treat arthritic conditions and promote collagen health. However, human-based research is lacking.
- Supports your brain as it ages
- Can improve kidney function-Your kidneys are particularly susceptible to oxidative damage, which is often irreversible
- Can inhibit infectious growth
- May reduce cancer risk-n lab studies, GSE has been shown to inhibit cancer in various human cell types.
- May protect your liver
- Enhances wound healing and appearance